Well, perhaps it was not explicitly clear that I was stating area, but….area is in “squared units”, inches squared, force is in lbs-force. The pressure value is equal to the amount of vacuum pulled, and it depends on what units the gauge is in as well as how the gauge is marked. Typically a vacuum gauge is marked in units of vacuum- psi, in hg, mm hg, in h2o, mm h2o. Too many variables to address. Get the reading of vacuum, convert to psi, and multiply it by the area of the opening in in^2. The most important thing is to have “measurement unit agreement”.
A vacuum gauge will self compensate for changes in atm pressure, so altitude is not an issue.