Ditto what Terry said. The wheels need to be either removable or can be lifted or cranked up out of the way. I've seen some good ideas over the years and come up with one or two myself.
The simplest but not good for heavy lathes is to have a hinged platform that the wheels fix to. Lift one end of the lathe and push the wheels under, move it, lift the lathe and flip them back out. Works great for my router table but not worth a darn for my 750lb powermatic.
I saw a nice system last weekend when I went to Indyfest. Ray had installed 3 boat trailer front wheel lifts. Crank the wheels down until it lifts the lathe and then roll it where you want to go. He did install pins in 2 of the wheels so they didn't rotate. He said that made it easier to control where the lathe wants to roll. I like that idea and may look at installing 4 of them on my Powermatic.
When I had to move I just had days to come up with system to move my lathe. I built some wooden platforms that had a metal lip. I attached 2 wheels to this. I raise the lathe with a floor jack, slide the wheels under and then lower the lathe. the L shaped platforms lock onto the lathe and I can roll it wherever I want. It is a little slow getting set up but then I only move this lathe once ever few years.