Tom, I don't know the answer, but I'd guess wood under the sapwood layer is probably fine. In my area (MN), when DED wiped out countless trees in the 1970s and 80s (when I was a kid the entire street canopy was a tunnel of elm, and it all died, later removed in one week leaving nothing behind but the clear blue sky), it seems a popular tree to replace it with was ash. Ash, and ash, and ash. Ash trees everywhere. And 30 years later, enter the emerald ash borer bug. Bye-bye ash trees, darn near every one of them. Now in summertime ash trees are identifiable from a block away because they are all dead or dying. And birch forests in the northern part of my state suffer from birch blight issues.
Moral of the story- urban trees and rural forestry can't be sustained around single species, because remember, nature likes a balance. Forests of all regions need biodiversity to survive.