Well I have done it with both INlace and Epoxy. Ideally you need to drill or cut out an area larger than just the pith. Not a lot but the further you get away from the pith the fewer problems you have in the future. I have also been known to leave the actual pith if it doesn't have cracks and just enlarge the cracks created outside the pith area. I fill those with epoxy or Inlace. You will have to back up the area you want to fill with tape and then pour into the void and overfill. Carve, sand or turn it down flush after it dries.
worse case scenario, it doesn't work and you have to toss it anyway, so really nothing is lost in trying and you learn a new process while doing it.